Am J Dis Child 1987 Jun;141(6):698-700

Hepatocarcinoma in a child with the Alagille syndrome

Kaufman SS, Wood RP, Shaw BW Jr, Markin RS, Gridelli B, Vanderhoof JA

Abstract
A child with the Alagille syndrome of intrahepatic bile duct paucity developed
hepatocarcinoma. Disabling cirrhosis had rendered this child a suitable
candidate for transplantation before the discovery of carcinoma. However, the
extension of the tumor outside the liver precluded the performance of this
potentially life-saving operation. Serial monitoring of the serum
alpha-fetoprotein concentration may be of value in the early identification of
tumors in pediatric candidates for transplantation